Custom Peptides
Cayman Chemical Dehydrocostus lacton 10mg
A natural sesquiterpene with anti-cancer and anti-inflammatory actions
Cayman Chemical SynthetIc NImbIn 10mg
A limonoid with diverse biological activities; inhibits the growth of D. oryzae by 64.8% at 1,000 ppm; has antifeedant activity against S. littoralis in a choice test at 0.02-2,000 μM; decreases melanin content to 20.9% of control in B16 murine melanoma cells at 25 μg/ml; inhibits TPA-induced activation of EBV-EA in Raji cells (IC50 = 499 mol ratio/32 pmol TPA)
Cayman Chemical NhexadecnoylLHomoserIn l 10mg
One of a number of lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in Sinorhizobium meliloti, a nitrogen-fixing bacterial symbiont of certain legumes; the most abundant AHL produced by the proteobacterium Rhodobacter capsulatus; activates genetic exchange between R. capsulatus cells
Cayman Chemical Obatoclaxmesylate 10mg
An antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd ~500 nM); prevents interaction of these pro-survival proteins with Bax or Bak, inducing apoptosis; also induces autophagy in mouse embryo fibroblasts and in HeLa cell
Cayman Chemical NAADPsodIum salt 10mg
A secondary messenger that induces calcium mobilization; induces calcium release from endosomes and lysosomes via TPC2 and TPC1; induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis; induces VEGF-mediated angiogenesis in HUVECs; alkalizes lysosomal pH, arresting autophagic flux in mouse embryonic stem cells
Cayman Chemical Desacetylcinobufagin 10MG
An active metabolite of cinobufagin; cytotoxic to HepG2, K562, and HL-60 cells (IC50s = 51.2, 50.1, and 7.5 µM, respectively)
Cayman Chemical F9170trIfluoroacetAT salt 10mg
An antiviral peptide; binds to the LLP1 domain within the HIV-1 envelope protein cytoplasmic tail; inhibits HIV-1 IIIB infection of MT-2 cells (EC50 = 0.19 µM); reduces plasma viral load in a rhesus macaque model of SHIV infection at 3 mg/kg
Cayman Chemical 7 Z-TrIcosen 10mg
An unsaturated cuticular hydrocarbon that acts as a pheromone in some insects, including Drosophila; abundant only in males of D. melanogaster and D. sechellia; prevents or reduces male courtship behavior and increases female sexual receptivity
Cayman Chemical IsosInsetIn 10mg
A polymethoxylated flavone with anticancer and anti-inflammatory activities; inhibits P-gp (IC50 = 4.2 µM); increases the cytotoxicity of paraquat in MDR1-MDCKII cells and paclitaxel in MX-1 and paclitaxel-resistant MX-1/T cells; inhibits the proliferation of A549, HL-60, MCF-7, and HO-8910 cells (IC50s = 23.6, 23.8, 15.1, and 12.5 µM, respectively); prevents PM2.5-induced decreases in cell viability and inhibits PM2.5-induced increases in IL-1β, TNF-α, IL-6, and ROS in 16HBE bronchial epithelial cells at 80 UG/ml
Cayman Chemical RAD17dRIved PeptIDtrIflu 10mg
A peptide substrate for ATR; has been used to identify inhibitors of ATR
Cayman Chemical BufuralolhydrochlorIde 10mg
A non-selective antagonist of β-ARs that also has partial agonist activity; decreases mean arterial blood pressure and increases abdominal aortic blood flow in anesthetized cats at 0.3 and 1 mg/kg; has been used as a substrate to measure CYP2D6 activity
Cayman Chemical Aranidipine 10mg
A Cav3.2 antagonist; inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels at 10 µM; decreases mean blood pressure and increases heart rate in SHRs at 10 mg/kg; It increases aortic and coronary blood flow and decreases blood pressure, but not heart rate, in normotensive dogs at 0.3 mg/kg; decreases blood pressure, as well as increases coronary blood flow velocity and heart contractile force, in dogs at 10 UG/kg; inhibits diet-induced increases in serum levels of total cholesterol, phospholipids, and triglycerides, as well as reduces aortic plaque area, in rabbits fed a high-cholesterol diet at 3 or 10 mg/kg
Cayman Chemical UNC2170maleate 10mg
A micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer; functions as a 53BP1 antagonist in cellular lysates
Cayman Chemical HArgGlyAspCysOHtrIfluo 10mg
An RGD-containing tetrapeptide; inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets (IC50s = 320 and 35 µM, respectively); implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs; has been conjugated to polyethylenimine to improve gene transfection efficiency