Custom Peptides
Cayman Chemical FerrostatIn-1 DIyn 10mg
An inducer of stop codon read-through restores the kinase activity of ATM in patient-derived A-T lymphoblastoid cell lines containing homozygous TAG TGA or TAA nonsense mutations in ATM at 10 and 30 M
Cayman Chemical SuccInylaceton 10mg
An anthelmintic agent a NAPE-PLD antagonist (IC50 2.1 UM) selective for NAPE-PLD over LPL and CA (IC50s 46 and 178 UM respectively) inhibits efferocytosis in primary mouse BMDMs at 10 UM inhibits TNF-a-induced NF-KB transcriptional activity in a reporter assay using HEK293 cells (IC50 11.2 UM) inhibits caspase-3 activity by 90 in a cell-free assay at 33 UM and prevents diphtheria toxin- cholera toxin- or P. aeruginosa exotoxin A-induced death in RAW 264.7 macrophages at the same concentration inhibits the replication of Zika virus in primary human astrocytes and Vero E6 cells (EC50s 5.5 and 6.3 UM respectively) decreases the number of G. salaris helminths in G. salaris-infected O. mykiss without inducing toxicity at 12.5 or 20 mg/L
Cayman Chemical FosaprepItnt dImeglumIn 10mg
A tyrosinase inhibitor (IC50 56 UM) found in cashew nut shell liquid halts the cell cycle at the S phase induces ROS accumulation and apoptosis and inhibits proliferation dose- and time-dependently in melanoma cells (IC50s 23.15 and 12.30 UM after 24 and 48 hours of treatment respectively) used as a mixture with cardanol di- and triene to synthesize cardanol-metal complexes that inhibit biofilm formation
Cayman Chemical 12methyl TrIDcnoIc ACD me 10mg
A cyclic heptapeptide containing GABA binds to phosphate pyrophosphate and chloride but does not affect chloride transport
Cayman Chemical AcrIdIn Ornge 10-nonylbro 10mg
A selective ETA receptor antagonist (IC50s 21 and 10000 nM for human recombinant ETA and ETB respectively) inhibits ET-1-induced growth of HEY OVCA 433 SKOV3 and A2780 cells in vitro reduces ET-1-induced expression of MMP-2 MMP-9 VEGF COX-1 and COX-2 in HEY cells reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner (10-50 mg/kg per day)
Cayman Chemical 15mthyl PalmItIc ACD mthy 10mg
An insecticide and GABAA receptor antagonist inhibits GABA-stimulated chloride uptake by membrane vesicles from rat cerebral cortex (IC50 68 M) binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s 1 12 505 833 150-1 675 nM for fruit fly house fly human mouse and rat respectively) a human recombinant B3 homooligomer with similar selectivity as a1B3Y2-containing receptors indicating that the binding site for Y-lindane on GABAA receptors is located on the B3 subunit (IC50s 0.90 21 and 306 nM for B3 a1B3Y2 and the native receptor respectively) blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s 1.74 and 148 nM respectively) toxic to mice and adult house flies (LD50s 40 and 5.5 mg/kg respectively) kills head lice in vitro and inhibits hatching
Cayman Chemical 10PnxtrIfluoroacetAT salt 10mg
An atypical antipsychotic selectively binds to the 5-HT receptor subtype 5-HT2A over 5-HT1A and 5-HT2C receptors (Kis 0 54 1480 and 173 nM respectively) binds to dopamine D1 D2 and D4 receptors (Kis 52 32 and 108 nM respectively) a1A- and a1B-adrenergic receptors (Kis 73 and 31 nM respectively) and SERT (Ki 61 nM) reduces quipazine-induced head-twitch behavior in rats (ED50 0 12 mg/kg)
Cayman Chemical Daphn genkwa GenkwnIn 10mg
An internal standard for the quantification of triclabendazole by GC- or LC-MS
Cayman Chemical cIs10hydroxy NortrIptylIn 10mg
A 5-HT1B receptor agonist selectively binds 5-HT1B over 5-HT1A 5-HT1C 5-HT1D and 5-HT2 (Kis 0 0081 1 5 2 9 1 1 and 7 2 UM respectively) inhibits potassium-induced GABA release from rat globus pallidus slices at 5 4 UM reverses reserpine-induced akinesia in a rat model of Parkinsons disease at 110 and 220 nmol/animal reduces food intake in rats when infused into the pons parabrachial nucleus or the PVN of the hypothalamus (ED50s 1 and 50 nmol respectively) reduces the frequency of pursuits tail rattles threats and attack bites in a resident-intruder test in mice
Cayman Chemical 10 11dIhydro10 11dIhydrxy 10mg
A TNAP inhibitor selective for TNAP over a panel of 35 targets at 10 UM increases survival and nearly completely inhibits the development of medial arterial calcification in a mouse model of CKD-MBD induced by a high-adenine high-phosphate diet at 10 and 30 mg/kg
Cayman Chemical DSethoxy QuetIapInhydroch 10mg
A saponin with diverse biological activities induces autophagic clearance of APP AB40 and AB42 in PC12 cells expressing APP695 Swe at 10 UM prevents the formation of hippocampal and cortical AB plaques and ameliorates spatial cognitive deficits in the transgenic APP/PS1 mouse model of Alzheimers disease at 40 mg/kg decreases lipid deposition in the aortic sinus and serum levels of MDA reduces aortic plaque area and increases serum levels of SOD GPX and catalase in ApoE-/- mice reduces spinal cord edema and neuronal apoptosis in a mouse model of mechanical compression-induced spinal cord injury at 10 and 50 mg/kg maintains retinal permeability and structure and reduces retinal levels of apoptotic proteins in a db/db mouse model of early diabetic retinopathy
Cayman Chemical 1Oleoyl2Lauroyl3PalmItoy 10mg
An inhibitor of TG2 (IC50 7 71 UM) cytotoxic against a panel of eight RCC cell lines (mean GI50 0 905 UM) suppresses tumor growth in ACHN and Caki-1 RCC mouse xenograft models at 8 mg/kg
Cayman Chemical OrnIpresInacetate 10mg
An antiarrhythmic agent inhibits acetylcholine or adenosine-induced potassium currents in isolated guinea pig atrial myocytes (IC50s 0 82 and 0 57 UM respectively) activates or inhibits hERG in a voltage-dependent manner activates KCa1 1/BKCa channels in HEK293 cells expressing Slo1 (EC50 20 2 UM) prolongs the duration of electrically stimulated action potentials in guinea pig papillary muscle ex vivo at 40 mg/kg a TRa and TRB antagonist (IC50s 2 2 and 4 1 UM respectively in reporter assays)